Atherosclerotic cardiovascular disease (CVD) such as acute heart atacks and stroke remains the leading cause of death worldwide. Both epidemiological and clinical studies have shown a strong link between inflammation, such as C-reactive protein (CRP), tumor necrosis factor (TNF)-alpha and interleukin (IL)-6, and the risk of cardiovascular events. Studies have also shown a strong link with inflammation and insulin resistance, an important determinant of CVD and diabetes.

So it all comes down to inflammation

In this study they investigated the link between inflammation insulin resistance and fat consumption and found insulin resistance linked with inflammation (hs-CRP and IL-6) and these inflammatory biomarkers were positively associated with saturated fatty acids and negatively associated with unsaturated fatty acids and monounsaturated fats. Dietary components, especially fatty acids, affect the expression and release of inflammatory biomarkers. Polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have a cardioprotective effect by reducing inflammation. Indeed, clinical studies have shown that diets may have effect on inflammatory biomarkers.

What does this mean?

One step to lower you inflammation and risk of CVD the major killer in in the world (and all chronic illness if you read my work) is to increase your omega 3 fatty acid and lower some of your saturated fats. There are many other ways to lower your inflammation and risk of chronic disease including lifestyle and dietary changes.

source

https://nutritionj.biomedcentral.com/articles/10.1186/s12937-018-0342-1